How hard have U.S. sanctions hit Iran's economy?

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The U.S. sanctions have severely affected Iran's oil-dominated economy. Between 2012 and 2016, Iran was estimated to lose out on around 150 billion U.S. dollars. Then in 2015, Iran signed the nuclear deal, which allowed it to start trading internationally again. But President Trump pulled the U.S. out of the accord last year. How effective has the strategy been?