A strip sack on the opening drive that set up a touchdown got the San Francisco 49ers off to a rousing start to a grueling three-game stretch.

A near flawless performance by Jimmy Garoppolo and a dominant performance by the defense finished off Aaron Rodgers and the Green Bay Packers.

Garoppolo threw two long touchdown passes and the San Francisco harassed Rodgers into one of the worst performances of his brilliant career, leading the 49ers to a 37-8 victory over the Packers on Sunday in the first of three straight games against first-place teams.

"Apparently nobody has to play us. We just have to play everybody. We're just the punching bag people come punch on," said cornerback Richard Sherman, clearly piqued by the talk of how difficult San Francisco's upcoming opponents are.

"We don't worry about the outside noise. We understand what kind of team we have and we don't worry about the opponent because you can't control what they do."

Garoppolo connected on a 42-yard touchdown strike to Deebo Samuel in the second quarter and a 61-yarder to George Kittle in the third to start this stretch for San Francisco (10-1) off on a high note.

Following this game against the first-place Packers (8-3), the Niners will travel to Baltimore (8-2) and New Orleans (9-2) the next two weeks in a stretch that will go a long way to determining whether San Francisco will be able to hold off Seattle (9-2) in a tight NFC West race.

"We crave every single game," defensive tackle DeForest Buckner said. "Every week is a new challenge. The good thing about this team is we don't get scared of who our next opponent is or 'Oh this team is supposed to be a top team.' It's just another team. We know how good we are. We just have to show it every chance we get."

Rodgers lost a fumble on the opening drive one of the five sacks he took and failed to convert a single third down on 13 tries before getting pulled late in the fourth quarter. He finished 20 for 33 for 104 yards and Green Bay averaged an anemic 1.7 yards per pass play when he was in the game.

"There wasn't a whole lot positive tonight," Rodgers said. "A lot of the stuff we talked about during the week, eliminating negative yardage plays, obviously we didn't do that. They got after us up front, and the coverage was good on the back end."

After allowing 78 points the past three weeks in two games against Arizona's Kyler Murray and one against Seattle's Russell Wilson, the Niners' defense was back to its dominant form.

San Francisco allowed 198 yards on 70 plays, didn't allow a single completion longer than 15 yards and got a key stop against Aaron Jones on a fourth-and-1 run in the first half when the outcome was still in doubt.

Garoppolo then put it away with the two long touchdowns, part of a day when he went 14 for 20 for 253 yards and most importantly committed no turnovers.

He was helped by the return of Kittle, who had six catches for 129 yards in his first game back after missing the past two contests with injuries to his knee and ankle.

"Our guys aren't just in there pumped about where we're at," coach Kyle Shanahan said. "They're pumped about the possibilities where we can go."

Other games on Sunday included (home teams in bold):

Tampa Bay Buccaneers 35-22 Atlanta Falcons

Denver Broncos 3-20 Buffalo Bills

New York Giants 14-19 Chicago Bears

Pittsburgh Steelers 16-10 Cincinnati Bengals

Miami Dolphins 24-41 Cleveland Browns

Carolina Panthers 31-34 New Orleans Saints

Oakland Raiders 3-34 New York Jets

Detroit Lions 16-19 Washington Redskins

Seattle Seahawks 17-9 Philadelphia Eagles

Jacksonville Jaguars 20-42 Tennessee Titans

Dallas Cowboys 9-13 New England Patriots