Manchester United manager Ole Gunnar Solskjaer admitted his decision to risk Marcus Rashford as a second half substitute "backfired" despite seeing his side progress to the fourth round of the FA Cup with a 1-0 win over Wolves on Wednesday.

Rashford lasted less than 15 minutes on the field due to a back injury and is now a doubt for the trip to runaway leaders Liverpool in the Premier League on Sunday.

The brief cameo from United's top goalscorer coincided with the only goal of the game as Juan Mata's clinical finish ensured United will travel to either Watford or Tranmere on January 26.

"That backfired, but you've got to go for them," Solskjaer told BT Sport. "He's got a knock and couldn't run. Let's test him for Sunday and see how he goes. He's had a few knocks with his back lately and he got another one."

Wolves put United out of the FA Cup last season and were unbeaten in five previous meetings between the sides since returning to the top flight in 2018.

Nuno Espirito Santo signaled his intent by making just one change from his side's Premier League clash with Newcastle at the weekend as John Ruddy replaced Rui Patricio in goal and Wolves looked likely to inflict more pain on the Red Devils in the first half.

Pedro Neto's strike was ruled out after a VAR review for handball against Raul Jimenez before Matt Doherty hit the post for the visitors.

"It's a frustration knowing we performed well, but we did not go to the next round," said Nuno.

At the other end, Ruddy made a fine save to deny Daniel James before the Welsh international then fired just wide of the far post early in the second half.

Rashford had come off on Saturday after scoring twice in a 4-0 thrashing of Norwich, with Solskjaer admitting the England international is carrying "quite a few knocks."

The Norwegian still ran the risk of introducing his star striker 25 minutes from time and within three minutes United led.

A rare moment of defensive disorganisation from Wolves allowed Anthony Martial to play Mata through on goal and the Spaniard coolly dinked the ball over the advancing Ruddy.

Rashford then went down holding his back and was replaced by Jesse Lingard.

His absence could be a huge blow to United's fight for a top-four finish in the Premier League and in three cup competitions with Solskjaer's side also still in the League Cup and Europa League.

Cardiff set up a fourth-round visit to Reading by edging a seven-goal thriller against fourth-tier Carlisle United 4-3.

Elsewhere, Cristiano Ronaldo was too ill to play, while Zlatan Ibrahimovic spent the evening resting on the bench, but even without their biggest stars, Juventus and AC Milan cruised into the last eight of the Italian Cup on Wednesday.

Juventus beat visiting Udinese 4-0 in the late game, after Milan had dispatched SPAL, 3-0. In the first game of the evening, 10-man Fiorentina beat Atalanta 2-1. 

Ronaldo was sidelined after suffering an attack of sinusitis in the afternoon, but he is not the only ace in the Juventus pack.

After 16 minutes, Paulo Dybala carved through Udinese with a series of quick one-twos, finishing with a couple of exchanges with center forward Gonzalo Higuain.

When his Argentine compatriot played a pass one little behind him, Dybala spun and floated the ball onto Higuain's chest and he strode forward and scored.

Ten minutes later, after Udinese goalkeeper Nicolas tripped Federico Bernardeschi. Dybala converted the penalty.

Dybala scored a in the 58th minute, clipping the ball over Nicolas from the right edge of the box. Two minutes later Douglas Costa converted Juve's second penalty after Bram Nuytinck handled.

In Milan, Krzysztof Piatek, who is reportedly on the verge of a move to Tottenham Hotspur, outpaced the sluggish SPAL offside trap to give the home team the lead after 20 minutes.

Samuel Castillejo curled a precise left-foot shot inside the far post just before half time. Fullback Theo Hernandez added a third in the 66th minute, surging upfield and smashing home a left-foot shot from just outside the penalty area.