Kevin De Bruyne orchestrated a dramatic Manchester City comeback on Wednesday as they stunned Real Madrid 2-1 at the Santiago Bernabeu to put one foot in the Champions League quarter-finals.

Madrid looked on course to edge a cagey contest after Isco's smart finish early in the second half, but De Bruyne teed up Gabriel Jesus in the 78th minute and then tucked away a penalty in the 83rd.

A pulsating finish also saw Sergio Ramos sent off for preventing Jesus from going clear and Madrid's captain will now be banned for the second leg at the Etihad Stadium on March 17, when City's two away goals will make them heavy favorites to go through.

"We tried to come here to win the game and we did. This is just the first part. If one team can overcome this situation, it's this club," City coach Pep Guardiola said. "When we were better, we conceded a goal. When they were better, we scored a goal. That's football."

Guardiola sprung another Champions League surprise by picking a line-up nobody predicted, with De Bruyne up front and Raheem Sterling, Sergio Aguero and Fernandinho all on the bench.

But his gamble paid off handsomely, even if Nicolas Otamendi made the mistake that led to Isco's opener while an injury to Aymeric Laporte meant Fernandinho had to be introduced midway through the first half.

Laporte was seen walking around the pitch but must now be doubtful to play in Sunday's League Cup final against Aston Villa.

Guardiola insisted on Tuesday that UEFA's two-year ban, pending City's appeal, would not act as a spur for his players but it was very much on the minds of their travelling fans, who were singing against European football's governing body from almost the first minute.

"It's just the first part, it's not three points. If one team can overcome this situation, for experience, for everything, it is this club, but of course it is a good result," Guardiola told BT Sport.

"I am so proud of course but it is just the first step, we have another game, it is not over. So be calm, enjoy it, enjoy the moment. Have a good dinner, good regeneration, on Sunday we have a final, keep going in the Premier League and prepare the second game against Madrid."

Meanwhile, Cristiano Ronaldo drew a blank as a Lucas Tousart goal handed Lyon a surprise 1-0 win over Juventus in the first leg of their Champions League last-16 tie in France.

The match went ahead before a full house at the Groupama Stadium, including around 3,000 Juventus supporters allowed to attend despite calls from some French politicians to block their access amid fears about the spread of the coronavirus.

Midfielder Tousart netted in the 31st minute to give Lyon a lead to defend when they head to Turin for the return on March 17.

The goal came with Juventus defender Matthijs de Ligt off receiving treatment, but it was just reward for an excellent first half by a Lyon side enduring a mediocre campaign.

They then survived late Juventus pressure to claim their finest European result since defeating Manchester City in last season's group stage.

Maurizio Sarri's side have genuine ambitions of winning a trophy that has evaded Juventus for almost a quarter of a century now, but they could not claim a precious away goal here, with Paulo Dybala seeing a late effort disallowed.

"In the first half it was not the Juve that we know. We didn't get going in attack. I am struggling to understand certain things," said Sarri, who thought his team could have had two penalties.

"We didn't do enough given this was a Champions League match but fortunately we still have 90 minutes to turn it around."