Vibrant Chelsea made it a torrid few days for Liverpool as goals by their Brazilian forward Willian and English midfielder Ross Barkley sealed a 2-0 victory to send them through to the Football Association (FA) Cup quarterfinals on Tuesday.

Liverpool's 44-match unbeaten streak in the Premier League ended in stunning fashion with a 3-0 defeat at Watford on Saturday and they were rocked again at Stamford Bridge.

Keeper Adrian, in for the rested Alisson, endured a horrible moment when he allowed Willian's powerful shot to bounce off him and into the net in 13th minute.

To complete a miserable night for Liverpool, former Everton midfielder Barkley drove home Chelsea's second goal just past the hour mark after a surging run.

Eight-time winners Chelsea thoroughly deserved their win and manager Frank Lampard will take heart from the fact that on the last two occasions they have beaten Liverpool in the Cup they have gone on to lift the trophy.

"They are the best team in the land; this year what they are doing in the league is incredible," Lampard said.

"So for us to put in the effort, focus, determination and quality was something special tonight. It's a one-off I know, but you have to celebrate these moments."

After having their dream of an unbeaten season wrecked at Watford, Liverpool's manager Jurgen Klopp made seven changes but still started with Virgil van Dijk, Sadio Mane, Joe Gomez, Andy Robertson and Fabinho – a far cry from the previous round at Shrewsbury when he fielded a virtual under-21 side.

It was clear from the start that Klopp wanted an immediate response to the Watford shocker, and he almost got it with Mane failing to capitalize on a golden early chance.

For Liverpool, a season of utter dominance which will almost certainly deliver a first league title for 30 years, has suddenly hit the buffers.

"We deserved to lose because they scored twice and we made massive mistakes for both goals," Klopp said.

"Nobody has to feel sorry for us, we will win football games and that is what we want to do on Saturday."

Also on Tuesday, Paraguayan midfielder Miguel Almiron struck twice as Newcastle United reached the FA Cup quarterfinals for the first time since 2006 with a 3-2 win at second-tier West Bromwich Albion.

Sheffield United joined the Magpies in the last eight but needed extra time to see off Reading 2-1.

FA Cup:

A total of eight teams will enter the FA Cup quarterfinals after their fifth-round matches.

So far, four quarterfinalists have been confirmed: Arsenal, Chelsea, Reading and Newcastle United.

Other matches left in the fifth round:

Sheffield Wednesday vs. Manchester City

Leicester City vs. Birmingham City

Tottenham Hotspur vs. Norwich City

Derby County vs. Manchester United

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Arsenal reach FA Cup quarterfinals to ease Euro woe