A total of 401 people in a prison in Cook County, Chicago, tested positive for the coronavirus, said the Cook County jail on Wednesday.
The prison, which houses 4,700 inmates, said 251 prisoners and 150 staff members had contracted the virus.
Among them, 22 have been hospitalized and 33 were taken to a rehabilitation facility.
One inmate has "apparently" died of the coronavirus, the jail said.
On Wednesday, the U.S. recorded nearly 2,000 COVID-19 deaths for the second day in a row, according to Johns Hopkins University, bringing the total number of U.S. fatalities to over 14,000.