U.S. stocks closed mixed on Monday as investors' concerns grew over economy reopening amid uncertainties from the COVID-19 pandemic.

The Dow Jones Industrial Average fell 109.33 points, or 0.45 percent, to 24,221.99. The S&P 500 rose 0.39 points, or 0.01 percent, to 2,930.19. The Nasdaq Composite Index increased 71.02 points, or 0.78 percent, to 9,192.34.

Seven of the 11 primary S&P 500 sectors ended lower, with financials and energy down 1.94 percent and 1.69 percent, respectively, leading the laggards. Health care and technology were up 1.67 percent and 0.7 percent, respectively, leading the gainers.

The mixed finish came as a growing number of U.S. states started to ease restrictions on business.

"Investors will be keen to see whether economies can sustainably reopen without the threat of a significant second wave of new coronavirus cases, especially since multiple economies, which have already begun reopening, have reported setbacks," UBS Global Wealth Management's Chief Investment Officer Mark Haefele said in a note.

For the week ending May 8, the Dow advanced 2.6 percent, the S&P 500 gained 3.5 percent, and the Nasdaq climbed six percent.

The S&P 500 posted 18 new 52-week highs and one new low; the Nasdaq Composite recorded 104 new highs and 10 new lows.

Volume on U.S. exchanges was 10.09 billion shares, compared with the 11.39 billion average for the full session over the last 20 trading days.

First-quarter earnings season is nearing the final stretch, with 440 of the companies in the S&P 500 having reported. Of those, 67.5 percent have beaten Wall Street estimates, according to Refinitiv data.

As of Monday afternoon, more than 1.34 million confirmed COVID-19 cases have been reported in the United States, with over 80,000 deaths, according to the Center for Systems Science and Engineering at Johns Hopkins University.

(With input from Xinhua and Reuters)