Manchester United's Premier League title challenge suffered a second setback in four days as they failed to breakdown an under-strength Arsenal in a 0-0 draw at the Emirates on Saturday.

United threw away top spot with a shock 2-1 defeat to bottom-of-the-table Sheffield United in midweek and are now three points adrift of league leaders Manchester City having played a game more than their local rivals.

Manchester City are clear at the top of the Premier League after Gabriel Jesus sealed a 1-0 win against Sheffield United.

A point edges eighth-placed Arsenal to within six points of the top four, and it was the Gunners who came closest to scoring when Granit Xhaka's free-kick struck the bar in the second half.

Unlike the early days of Ole Gunnar Solskjaer's reign, it is against their traditional top six rivals that the Red Devils' challenge for a first league title since 2013 has faltered.

United have still yet to beat any of City, Liverpool, Tottenham, Chelsea or Arsenal in the league in six attempts this season.

After winning at Old Trafford three months ago, the Gunners went seven league games without a victory but have bounced back in recent weeks.

Mikel Arteta's men are now unbeaten in seven to move back into contention for a top-four finish, but will rue missing their chances in the second half to take all three points despite a number of key absences.

Two of Arsenal's most impressive performers this season, Kieran Tierney and Bukayo Saka, were missing through injury, while captain Pierre-Emerick Aubameyang was also absent for the third consecutive game due to his mother suffering from an illness.

After a tentative start from both sides, Bernd Leno made a brilliant save to deny Fred a clever opener for United as the Brazilian tried to lob the ball in from the edge of the box.

Arsenal had a number of half-chances before the break without testing David de Gea as Thomas Partey and Nicolas Pepe shot just wide from the edge of the box and a teasing cross from Gabriel Martinelli just evaded Alexandre Lacazette.