Novak Djokovic survived a five-set scare while Rafael Nadal shone in the Paris sun as the two Grand Slam heavyweights reached the French Open quarter-finals for the 15th time, stalling the advance of tennis's next generation.

World number one Djokovic stayed on course to become the first man in over 50 years to win all four Slams twice but only after fighting back from two sets down to see off 19-year-old Lorenzo Musetti.

Nadal, the 13-time champion and bidding for a record 21st major, claimed his 104th win in Paris by beating another Italian 19-year-old, Jannik Sinner, in straight sets.

Meanwhile, in the women's draw, Coco Gauff, Barbora Krejcikova and Maria Sakkari all reached the quarter-finals of a Slam for the first time while defending champion Iga Swiatek cruised through.

Musetti, ranked 76 and making his Grand Slam debut, was poised to condemn Djokovic to his earliest exit in Paris since 2009 when he captured the first two sets, 7-6 (9/7), 7-6 (7/2).

But Djokovic leveled by taking the next two, 6-1, 6-0 before Musetti, who had needed a medical time-out, retired at 4-0 down in the decider suffering from cramps and a back injury.

Third seed Nadal downed 18th-seeded Sinner 7-5, 6-3, 6-0 and goes on to face Diego Schwartzman of Argentina, whom he defeated in the semi-finals in 2020.

Nadal has now won 104 matches at Roland Garros against just two defeats since his 2005 debut while Monday's victory extended his run of consecutive sets won in Paris to 35.

The 35-year-old Spanish world number three is seeded to face Djokovic in the semi-finals.

"I started well but was a little too defensive. I gave him the chance to come inside the court and play his best shots. That was a mistake," said Nadal after reaching a 44th Slam last-eight. "I broke back at 5-4 in the first set and the match changed after that. I played at a great level."

Nadal hit 31 winners while the Italian claimed just 10 points in the third set.

Schwartzman, the 10th seed, reached his third French Open quarter-final with a 7-6 (11/9), 6-4, 7-5 win over Germany's Jan-Lennard Struff.

Gauff swept to an impressive 53-minute, 6-3, 6-1 win over Tunisia's Ons Jabeur. At just 17, she is the youngest woman to reach the last eight of a Slam since Nicole Vaidisova at the 2016 French Open.

In a composed performance on Court Philippe Chatrier, the American teenager, seeded 24, broke her Tunisian opponent three times without facing a break point.

Gauff, who famously raced to the Wimbledon fourth round in 2019 as a 15-year-old qualifier, faces Krejcikova for a place in the semi-finals.

The 33rd-ranked Czech also reached her first Grand Slam quarter-final with a 6-2, 6-0 win over 2018 runner-up and former US Open champion Sloane Stephens.

Last year's runner-up Sofia Kenin, the fourth seed, was knocked out by Sakkari 6-1, 6-3 as the Greek reached her maiden Slam last-eight.

The world number 18 will next face reigning champion Swiatek, who clinched a 6-3, 6-4 victory over Ukrainian teenager Marta Kostyuk.

The eighth seed from Poland has won 22 straight sets at Roland Garros.

Swiatek, 20, is aiming to become the first woman to defend the title in Paris since Justine Henin won the tournament three times in a row from 2005 to 2007.