Novak Djokovic set up a 58th meeting with Rafael Nadal on Wednesday when he reached his 40th Grand Slam semi-final while Maria Sakkari stunned defending champion Iga Swiatek to become the first Greek woman to make the last four at a major.

World No. 1 Djokovic defeated Italy's Matteo Berrettini 6-3, 6-2, 6-7 (5/7), 7-5 to book his place in the Paris semis for the 11th time.

Nadal, the 13-time champion, beat Argentina's Diego Schwartzman 6-3, 4-6, 6-4, 6-0 to make the semi-finals for the 14th time.

With Djokovic's match extending beyond the national 11 p.m. curfew, play was halted for around 20 minutes at 3-2 in the fourth set so that 5,000 fans could be funneled out of Court Philippe Chatrier.

Djokovic eventually claimed the match on a third match point but only after he had kicked out at an advertising board in frustration at missing the first two.

"It was a release of all the emotions I had kept inside me," said Djokovic who hit 44 winners and saved all three break points he faced. "After all the fans left and the little break it wasn't easy to find rhythm. It was really a very difficult match for me."

Friday's semi-final will be the eighth match between Djokovic and Nadal at Roland Garros where the Spaniard has a commanding 7-1 advantage.

That includes last year's final but Djokovic remains just one of two men to have defeated Nadal at the tournament.

Djokovic, an 18-time major winner and 2016 French Open champion, is looking to become the first man in more than half a century to win all four Slams twice.

Nadal, meanwhile, can win a record-setting 21st major with victory in Sunday's final, edging ahead of Roger Federer in the all-time race.

For the first time fans were allowed to attend an evening session at this year's tournament thanks to an easing of Covid-19 restrictions.

The 5,000-strong crowd watched as Djokovic took command against Berrettini who had made the quarter-finals when Roger withdrew from the tournament.

However, play was halted just before 11 p.m. to allow spectators to leave.

Some chanted: "We are going to stay, we are going to stay" before they relented and filed out of Court Philippe Chatrier.

"We paid 500 euros for two-thirds of a match. It's unacceptable," said one man watching the quarter-final with his wife and two children.

Nadal defeated Schwartzman for the 11th time in 12 meetings, shrugging off seeing his winning run of 36 consecutive sets end.

The world number three improved his French Open record to 105 wins and just two losses as he advanced to his 35th Grand Slam semi-final. 

"It's always incredible for me to return to the semi-finals for another time," said Nadal.

Schwartzman also lost to Nadal in the 2020 semi-finals in Paris. "Next time, I want to be in the other side of the draw," said the rueful Argentine.

World number 18 Sakkari triumphed 6-4, 6-4 over Polish eighth seed Swiatek and will face 33rd-ranked Barbora Krejcikova of the Czech Republic for a place in the final.

Thursday's other semi-final sees Russian 31st seed Anastasia Pavlyuchenkova tackle unseeded Tamara Zidansek of Slovenia.

For the first time in the Open era, the French Open semi-finals will feature four women who have never previously got this far at the Slams.

Swiatek had gone into the match on the back of 22 consecutive sets won at the French Open but her challenge was curtailed by a right thigh injury which required taping during a medical timeout early in the second set.

Her defeat means that Justine Henin remains the last player to defend the women's title in Paris in 2007.

Krejcikova knocked out American 17-year-old Coco Gauff 7-6 (8/6), 6-3 after needing six match points to finish the job.