Brazil's World Cup South American qualifying clash against Argentina was dramatically suspended shortly after kick-off on Sunday as controversy over COVID-19 protocols erupted.

Amid incredible scenes at Sao Paulo's Neo Quimica Arena, the match between the two giants of South American football came to a halt when a group of Brazilian public health officials came onto the pitch, triggering a melee involving team staff and players.

Argentina's players trudged off the pitch to the changing room as the fury erupted. Argentina captain Lionel Messi later re-emerged from the tunnel without his team shirt on as confusion swept around the stadium.

The South American Football Confederation (CONMEBOL) said in a statement that the game had been "suspended" but did not say whether the match would resume or be replayed.

"By decision of the match referee, the match organized by FIFA between Brazil and Argentina for the qualifiers for the World Cup is suspended," the statement said.

"The referee and the match commissioner will submit a report to the FIFA Disciplinary Committee, which will determine the steps to follow. These procedures adhere strictly to current regulations."

The stunning intervention came just hours after Brazil's health authorities said four players in Argentina's squad based in England should be placed in "immediate quarantine" for breaching COVID-19 protocols.

According to Brazil's National Health Surveillance Agency (ANVISA), Premier League players Giovani Lo Celso, Emiliano Martinez, Emiliano Buendia and Cristian Romero provided "false information" upon their entry to Brazil.

Romero, Lo Celso and Martinez were all in the Argentina starting lineup that kicked off Sunday's game – triggering the intervention onto the field of officials wearing ANVISA shirts.

The four Premier League players – Lo Celso and Romero play for Tottenham, while Martinez and Buendia play for Aston Villa – were accused of failing to disclose that they had spent time in the United Kingdom in the 14 days prior to their arrival.

"We got to this point because everything that ANVISA directed, from the first moment, was not fulfilled," ANVISA Director Antonio Barra Torres said on Brazilian television.

"(The four players) were directed to remain isolated while awaiting deportation, but they did not comply. They went to the stadium and they entered the field, in a series of breaches," the official added.

A government order of Brazil dating from June 23 bans the entry into the country's territory of any foreign person from the United Kingdom, India or South Africa, to prevent the spread of variants of the coronavirus.

"ANVISA considers that this situation represents a serious health risk and recommends that the local health authorities (of Sao Paulo) order the immediate quarantine of the players, who are prohibited from taking part in any activity and from remaining on Brazilian territory," the agency said in a statement earlier on Sunday.

ANVISA said Brazil's federal police had been notified so that "the necessary measures are taken immediately."

Argentina coach Lionel Scaloni lashed out at Brazilian authorities following the game's suspension.

"It makes me very sad. We are the victims in the sense that we wanted to play the game, the Brazilian players also wanted to play it and the show was to be played," Scaloni told Argentina's TyCSports channel.

Scaloni said the match "should have been a party for everyone, to enjoy the match with the best in the world."

The controversy came after nine Brazilians based in the Premier League failed to travel to South America following objections from their clubs.