U.S. Senator Joe Manchin, a moderate Democrat who is key to President Joe Biden's hopes of passing a $1.75 trillion domestic investment bill, said he would not support the package.

"I cannot vote to continue with this piece of legislation," Manchin said during an interview with the "Fox News Sunday" program, citing concerns about inflation. "I just can't. I have tried everything humanly possible."

The White House called Manchin's remarks a breach of commitments he made to find common ground, and said it would find a way to move forward with the legislation in 2022.