The number of cases of a mysterious acute hepatitis in children continues to increase worldwide, with most cases occurring in Europe. As of May 10, 348 suspected cases had been reported in at least 20 countries. Information and data have pointed to an adenovirus called adenovirus-41 (HAdV-41) as the possible culprit. Does it have anything to do with COVID? Will it become a pandemic? How do we protect ourselves from it?