U.S. President Joe Biden arrives in the Middle East on Wednesday for his first trip to the region since he took office. The 79-year-old president will meet Israeli leaders seeking to broaden cooperation. This comes as Iran and Palestinian leaders are frustrated by what they describe as Washington's failure to curb Israeli aggression. Also on the agenda is the rejuvenation of the Iran nuclear deal, which was reached by Barack Obama in 2015 and abandoned by Donald Trump in 2018. Negotiations stalled last month.