A Los Angeles County resident with a compromised immune system has died from monkeypox, local health officials announced Monday. It's believed to be the first U.S. fatality from the disease.

The Los Angeles County Department of Public Health announced the cause of death, and a spokesperson said it was confirmed by an autopsy. The patient was severely immunocompromised and had been hospitalized. No other information on the person was released. 

The U.S. Centers for Disease Control and Prevention (CDC) tracks cases and has not yet confirmed any U.S. deaths from the disease. LA County officials say they worked with the CDC on their case.

A CDC spokesperson confirmed the cooperation but did not immediately respond when asked if this was the first U.S. death.

Texas public health officials on August 30 reported the death of a person who had been diagnosed with monkeypox. The person was severely immunocompromised and their case is under investigation to determine what role monkeypox may have played in the death.

The United States has the most cases globally, with 21,985 confirmed as of Monday, according to the CDC. California has recorded the most cases nationally, with more than 4,300.

Monkeypox is spread through close skin-to-skin contact and prolonged exposure to respiratory droplets. It can cause a rash, fever, body aches and chills. Relatively few people require hospitalizations and only a handful of deaths worldwide have been directly linked to the disease.

(With input from AP)