Multiple Israeli strikes on Syria's Hama countryside late on Sunday killed at least four civilians, Syrian state media reported, with sources saying the attacks targeted a major military research center.

A local health official quoted by Syria's state news agency said 13 people were also injured, including several critically, following Sunday's strikes in the vicinity of the city of Misyaf, with ambulances still ferrying the wounded.

Two regional intelligence sources said a major military research center for chemical arms production located near Misyaf was hit several times.

There has been no immediate comment from Israel.