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Although Cai Lei can no longer speak, his message remains powerful. Through an AI-generated voice, he advocates for stronger interdisciplinary collaboration in ALS research. His unconventional approach has produced tangible results: 40 ALS clinical pipelines have been established in China over the past five years, and more than 200 drug pipelines and treatment pathways are now available. For Cai Lei, this marks the end of the first chapter. The next chapter will be shaped by those who continue the fight.