The death toll has risen to 46 from Wednesday's high-speed train collision in Toledo province, Spain, local media reported, citing civil protection sources.

According to Spanish newspaper ABC, the crash involved a Renfe AVE train and an Iryo train, causing two carriages of the Iryo train to derail. Witnesses reported numerous injuries.

Spanish Prime Minister Pedro Sanchez said he was "shocked" by the serious collision, adding that emergency services are on the ground to assist those impacted.