Portugal became the first team to qualify for the Nations League FInals when they held Italy 0-0 on Saturday, the second time in a year that the hosts have been knocked out of the competition following a goalless draw at the San Siro.
Italy's defender Giorgio Chiellini making his 100th appearance, as the team suffocated Portugal in the first hour with their pressing and created numerous openings with their intricate passing moves.
But they ran out of steam in the last half hour and the European champions held out fairly comfortably.
Portugal has seven points from three games in the three-team group, two ahead of Italy who have finished their campaign. Poland, who visit Portugal for the group's final game on Tuesday, has one point and have already been relegated.
They are also in line to host the semi-finals and finals in June as Italy and Poland were the only other two countries to express an interest in staging the tournament. The decision still has to be ratified by UEFA on December 3.
Last November, Italy failed to qualify for the World Cup for the first time in 60 years after being held by Sweden at the same stadium in Milan.
Italy head coach Mancini issues instructions to Alessandro Florenzi during their UEFA Nations League clash with Portugal at Stadio Giuseppe Meazza on November 17. /VCG Photo
A small part of the crowd booed Italy defender Leonardo Bonucci, who left AC Milan after one season at the club to return to Juventus in August.
Italy had an early chance when Lorenzo Insigne's long-range shot was parried by Rui Patricio, and Ciro Immobile blasted the rebound over the bar.
In what was a hugely promising display by Roberto Mancini's side, Alessandro Florenzi drove a low shot narrowly wide before Marco Verratti threaded a ball through to Immobile and this time Patricio saved the shot with his leg.
Another neat moved ended with Jose Fonte blocking Federico Chiesa's shot early in the second half.
Portugal, who have not picked Cristiano Ronaldo since the World Cup by mutual agreement, was more threatening as the game wore on.
Substitute Joao Mario shot over on the turn after Joao Cancelo worked an opening on the right and Gianluigi Donnarumma made a difficult save from William Carvalho's low shot.
Lorenzo Pellegrini's header was comfortably saved by Patricio as Italy had a final fling in stoppage time.