The US has resorted to a variety of means to challenge Iran's independence over the past 40 years, Iran's Supreme Leader Ayatollah Ali Khamenei said on Saturday. As a matter of fact, the interaction between the two countries can be traced back to earlier. Here is a quick look at US-Iran relations. 

Read more:

Iran calls US 'loser' as new US sanctions loom

For this year, the US withdrew from the historic 2015 Iran nuke deal known as the Joint Comprehensive Plan of Action (JCPOA) on May 8 and announced two rounds of sanctions imposed on Iran taking effect on August 7 and November 5 respectively.