CNN's New York offices and studios were evacuated for more than an hour after a caller said there were five bombs hidden in the Time Warner Center Building, disrupting the broadcaster's schedule, police said.
The "all clear" was given by police shortly before midnight (0500 GMT) after several dozen police officers conducted a "comprehensive sweep-and-search".
Fire alarm bells rang inside the newsroom to signal an evacuation shortly after 10:30 p.m. local time, CNN said on its website.
Staffers evacuated the building and Don Lemon's "CNN Tonight" was taken off the air.
The New York Police Department tweeted West 58th Street between 8th and 9th Avenue is now open to pedestrian traffic after a police investigation at Columbus Circle.
Nothing suspicious was found, CNN reported.
Network's bureau in the Time Warner Center was evacuated in October due to a package with an explosive device.