Avengers assembled in full force at the box office this weekend.

“Avengers: Infinity War” took North America by storm, opening with 250 million US dollars in 4,474 theaters. While numbers could fluctuate before an official tally comes in on Monday, that would surpass “Star Wars: The Force Awakens” for the biggest domestic opening weekend of all time. “The Force Awakens” bowed with 248 million US dollars in 2015.

The superhero tentpole, which cost between 300 million US dollars and 400 million US dollars, opened worldwide with 630 million US dollars, making it the highest global opening weekend of all time, even without China debuting this weekend.

“It is an extraordinary weekend for the movie business and for the Marvel Cinematic Universe,” Dave Hollis, head of domestic distribution at Disney, said. “‘Infinity War’ was the culmination of 10 years of developing the universe and characters that people care about. Having them all come together in this was what created a must-see moviegoing event.”

Prior to “Infinity War,” the original “Avengers” had the highest opening to date for a Marvel film, debuting with 207.4 million US dollars. Its sequel, “Age of Ultron,” launched with 191 million US dollars. The first movie earned 623 million US dollars in North America, while the second made 459 million US dollars.

Joe and Anthony Russo directed from a script by Christopher Markus and Stephen McFeely. “Infinity War” picks up two years after the events of “Captain America: Civil War” with the Avengers teaming up with the Guardians of the Galaxy to stop the evil Thanos (Josh Brolin) from inter-galactic dominance.

The heroic ensemble cast includes Robert Downey Jr.’s Iron Man, Chris Hemsworth’s Thor, Chris Evans’ Captain America, Scarlett Johansson’s Black Widow, Chadwick Boseman’s Black Panther, Chris Pratt’s Star Lord, Benedict Cumberbatch’s Doctor Strange, and Mark Ruffalo’s Hulk.

With no other films opening in wide release in the wake of “Infinity War,” Paramount Pictures’ “A Quiet Place” secured second place with 10.6 million US dollars in 3,565 locations. The thriller – directed by John Krasinski and co-starring Krasinski and Emily Blunt – continues its impressive run with a domestic total of 148 million US dollars in four weeks. Due to the film’s monster success, Paramount’s head Jim Gianopulos announced a sequel was in the works.

In third place, STX’s “I Feel Pretty” scored 8 million US dollars from 3,440 theaters in its second weekend. That brings the North American tally on Amy Schumer’s latest comedy to 29 million US dollars. Meanwhile, Dwayne Johnson’s “Rampage” dropped down to the fourth slot, earning 7.1 million US dollars in 3,508 locations. The Warner Bros. actioner has made 77.9 million US dollars domestically in its three weeks of release.

Rounding out the weekend is another Marvel title, “Black Panther.” In its 11th weekend, the tentpole made 4.6 million US dollars, bringing its domestic total to 688 million US dollars. Globally, “Black Panther” has collected 1.3 billion US dollars. With “Infinity War’s” massive debut, Marvel’s 19 titles have collectively grossed 15 billion US dollars worldwide.

“Infinity War” has ignited a spark in the box office. Prior to this weekend, the year to date box office was down 2.8 percent. After this weekend, the 2018 box office is up 3.2 percent compared to 2017, according to comScore.

“‘Avengers: Infinity War’ demonstrated yet another Marvel superhero power,” Paul Dergarabedian, an analyst at comScore, said. “The ability to reverse a downtrending box office year with a single knockout punch and literally change the box office fortunes of Hollywood almost overnight.”