Ajax stunned Juventus to reach the Champions League semi-finals for the first time since 1997 as Matthijs de Ligt's thumping second-half header secured a 2-1 second-leg victory in the last eight in Turin on Tuesday.

Cristiano Ronaldo, bidding for his sixth Champions League title, scored a 28th-minute header to put Juve ahead after a 1-1 first-leg draw, but Donny van de Beek leveled for Ajax before half-time.

Teenage center-back De Ligt struck midway through the second period, though, to seal a 3-2 aggregate win and set up a last-four clash with either Manchester City or Tottenham.

The young Dutch side had already eliminated three-time defending champions Real Madrid en route to the quarters, overturning a 2-1 home defeat against the Spanish side with a memorable 4-1 victory at the Santiago Bernabeu.

"It's an incredible evening for Ajax and its players and also for Dutch football," said coach Erik ten Hag.

"Once again we eliminated the favorites.

"We said before we were not the favorites but with our philosophy, we can go further, we've again surpassed our limits."

Juventus had been looking to reach the Champions League semi-finals for the third time in the past five seasons.

But Ronaldo, who scored an away goal last week with a diving header in Amsterdam, was Juve's only weapon against the impressive Dutch side.

"Ajax deserved to qualify," said Juve coach Massimiliano Allegri.

"We could have done better, but Ajax aren't coming out of nowhere, they were Europa League finalists two years ago and scored five goals against Real.

"It's not our worst elimination. We had big expectations, but the Champions League is a strange competition. You have to arrive in peak condition.

"In the last month, we have been struggling with several injuries. Even tonight we were missing important players."

It was the Portugal star's 126th Champions League goal and sixth of this campaign, having now scored in his past six European games against Ajax, netting nine goals in total.

Four-time winners Ajax won their third consecutive title in 1973 at the expense of Juventus, and last lifted the trophy in 1995, with their last semi-final appearance ending in defeat by Juve 22 years ago.

Juventus now turn their focus back to Serie A where they can win an eighth consecutive title on Saturday.

"Ronaldo had a good match, he scored. He's disappointed like all of us," said Allegri. "Saturday we have to close out the Scudetto."

Messi double as Barca cruise into semis

Lionel Messi pounced on two Manchester United mistakes to score twice and end their hopes of another comeback at Camp Nou as Barcelona breezed into the Champions League semi-finals on Tuesday.

After an excellent start, United were undone twice in four minutes by Messi, who first nicked the ball off the careless Ashley Young and then watched as a weak shot from distance squirmed underneath David de Gea.

Philippe Coutinho, in perhaps his best performance of the season, added a third with a curling effort into the top corner and by the end, an outclassed United might have been relieved the score was not more traumatic than 3-0, 4-0 on aggregate.

"We had five uncomfortable minutes because they came out strong," said Barcelona coach Ernesto Valverde. "But then there were another 85 minutes where we weren't bad."

A dizzying opening spell, in which Marcus Rashford had hit the crossbar, was long-forgotten, even if it could offer Barca's next opponents some encouragement.

Instead, United's pair of early errors made this another night about Messi and ensured any faint hopes of repeating the comeback against Paris Saint-Germain, or even the famous 1999 rescue act against Bayern Munich, on this same pitch, were dashed.

"We said all along this was not going to change overnight," United's coach Ole Gunnar Solskjaer said. "In the next few years, it is going to be a massive effort to get to the level of Barcelona and these sorts of teams."

Messi now has his 109th and 110th Champions League goals and, potentially, three extra matches to reduce the gap on Cristiano Ronaldo's 126, after Juventus were dumped out by Ajax. Barcelona's fans celebrated that too.

Solskjaer had urged his strikers to be more lethal here but it felt ominous that even before kick-off, Rashford, Anthony Martial, Romelu Lukaku and Alexis Sanchez had hit 42 goals this season, while Messi on his own had 43.

Around an hour before kick-off, Alex Ferguson was on the side of the pitch, shaking hands with Ryan Giggs and sharing words with Solskjaer, the scorer of the winning goal against Munich here 20 years ago.

They could have hardly have asked for a better start. United were brilliant for eight minutes and could have been ahead within 30 seconds as Rashford raced onto a curving Paul Pogba pass and toed away a shot, which Marc-Andre ter Stegen bravely left to graze his own crossbar.