The Boston Celtics still own the Philadelphia 76ers no matter who is on the court.

Gordon Hayward scored 26 points, including a go-ahead 3-pointer with 1:50 remaining, and Boston beat Philadelphia 112-109 on Tuesday night. Al Horford had 23 and Jayson Tatum scored 20 and grabbed 10 rebounds to help the Celtics continue their dominance over the Sixers.

Playing without All-Star point guard Kyrie Irving, who sprained his right knee Saturday night, the Celtics beat the Sixers for the third straight meeting this season after defeating them in five games in the Eastern Conference semifinals last season.

“Against a very quality opponent was big, especially on the road without Kyrie, it was huge,” Hayward said.

Joel Embiid had 23 points and 14 rebounds and Jimmy Butler scored 22 for Philadelphia.

Hayward's 3 from the corner put Boston up 105-103 and Marcus Smart added a free throw. The Sixers had a chance to tie when Jimmy Butler went to the line for three free throws but he missed two. After a turnover, Embiid lost the ball with under a minute left. Smart then blew past Ben Simmons for a dunk to extend the lead to 108-104 with 24 seconds left. Butler made a driving layup and a free throw to cut it to 108-107.

After Horford sank two free throws, Tobias Harris missed a 3 and Embiid put it back in with only 2.4 seconds left. Butler couldn't get a desperation 3 off in time before the buzzer sounded as the Sixers dropped their first game in three since acquiring Harris in a flurry of moves last week.

“This is a new team,” Simmons said. “There are things we're going to work on, things we need to get better at, but it's a good test for us to see where we're at with this new team. But I'm excited with everyone we have and to see how far we can go.”

The Celtics answered the call in their first game since Marcus Morris questioned the team's toughness after they surrendered leads of 28 points to the Clippers and 18 points to the Lakers on their home court.

“Good teams have clunkers, but good teams respond to those with the right effort and approach,” Celtics coach Brad Stevens said.

Both teams are tied for the fourth spot in the East with a 36-21 record.

“We understood Philly's been playing at a high level,” Horford said. “We had disappointing losses at home. I felt like our backs were against the wall, so we all needed to come out and set the tone and we did that.”

After trailing for nearly the entire first half, the Sixers opened the third quarter on a 9-0 run to take a 55-52 lead. JJ Redick's 3-pointer capped the run. Minutes later, Simmons thrilled the crowd by driving around Tatum and throwing down a thunderous right-handed jam. But Tatum answered at the opposite end with a spin move around Embiid and dunk over Simmons.

Other games on Tuesday  include: (with the home team in bold)

Atlanta  Hawks                   117-113  Los Angeles Lakers        

San Antonio Spurs               108-107  Memphis Grizzlies  

Orlando Magic                      118-88   New Orleans Pelicans   

Golden State Warriors       115-108   Utah Jazz