A suicide bomber blew himself up in a banqueting hall where Islamic religious scholars had gathered in the Afghan capital Kabul on Tuesday, killing at least 50 people, three government officials said.

More than 80 other people were injured, said Najib Danish, a spokesman for the Interior Ministry.

"A suicide bomber detonated his explosives inside a wedding hall where Islamic religious scholars had gathered to commemorate the anniversary of the Prophet Mohammad's birth," Danish said.

The banquet room is in the Uranus wedding hall, a complex housing several large reception rooms near Kabul airport.

"Hundreds of Islamic scholars and their followers had gathered to recite verses from the holy Quran to observe the Eid Milad-un-Nabi festival at the private banquet hall," said a spokesman for Kabul police.

Officials at Kabul's Emergency Hospital said 30 ambulances had rushed to the scene and over 40 people were critically wounded.

It's said to be one of the deadliest attacks in Kabul in recent months.

Both the Sunni Taliban militant group and a local ISIL affiliate have in the past attacked government-aligned religious scholars who have decreed that suicide attacks are forbidden by Islam.

But the Taliban said in a statement that "our men were not involved in the Kabul blast and we condemn the loss of human lives."

The radical Sunni militant group ISIL has mostly focused its major attacks on Afghan soil on Shi'ite Muslim sites of worship, regarding Shi'ites as heretics.

President Ashraf Ghani called Tuesday's attack "un-Islamic" and "unforgivable." He declared Wednesday a day of mourning.

Afghan security forces have struggled to prevent attacks by Islamist militants since most NATO combat troops withdrew in 2014.

Despite diplomatic efforts to end the 17-year war, in recent months the security situation has deteriorated sharply.

The Kabul government now controls only 56 percent of Afghan territory, down from 72 percent in 2015, according to a U.S. government report issued this month.