A senior local official said 16 people were killed in the plane crash in Mississippi and a search operation is underway, according to CNN.
All the dead were on board the aircraft, said Fred Randle, county emergency management director.
The plane was loaded with explosives, keeping emergency responders at bay, a state trooper told media.
Investigators said that debris indicated the plane exploded in midair.
Updated at 10:30 a.m. BJT
A US military plane carrying nine people crashed in LeFlore County, in the southern US state of Mississippi on Monday evening, claiming at least eight lives, AP reported citing officials.
Mississippi Emergency Management Agency Director Lee Smithson said the C-130 military transporter crashed on the border of Leflore and Sunflower, another Mississippi town.
Officials did not reveal the cause of the crash or where the flight originated.
The local coroner's office has been called to the scene and its staff is looking for more victims, LeFlore County deputy coroner Will Gnemi said.